Neurobehavioral changes were observed in rats and mice treated with either DMT or TMT, but we also observed that both TMT and DMT exposure in rats significantly lowered the blood potassium level. Diets were mixed to contain 0,0.5,5 or 50 ppm Sn as either TMTC or TETC. Acute toxicity no data available Skin corrosion/irritation no data available Serious eye damage/eye irritation no data available Respiratory or skin sensitisation Germ cell mutagenicity no data available Carcinogenicity IARC: No component of this product present at levels greater than or equal to 0.1% is identified as Trimethyltin chloride (TMT) is an organotin contaminant, widely detected in aqueous environments, posing potential human and environmental risks. As PVC polymer is unstable under heat and light, OTs derivatives can be added as stabilizers (2). Trimethyltin hydroxide Revision Date 23-Jan-2018 Hazardous Polymerization Hazardous polymerization does not occur. Do not allow 2.2 Summary of clinical effects Depending on the dose, the symptoms may appear Chemsrc provides Trimethyltin chloride(CAS#:1066-45-1) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Figure 1 illustrates the e!ect of other compounds tested in this study is one or more orders cadmium and chromium(VI) on the mortality of A. francis- … Trimethyltin (TMT) is a toxic organotin compound that induces acute neuronal death selectively in the hippocampal dentate gyrus (DG) followed by cognition impairment; however, the TMT-injured hippocampal DG itself is reported to regenerate the neuronal cell … Trimethyltin and triethyltin are mildly toxic to humans, whereas tripentyltin is generally non-toxic and is therefore applied as a pesticide. To elucidate the mechanisms underlying the toxicity of TMT toward neurons, we prepared primary cultures of neurons from the neocortex of mouse embryos. Trimethyltin chloride (TMTC) and triethyltin chloride (TETC) were fed to mallard (Anas platyrhynchos) ducklings for 73 to 75 d, beginning when ducklings were 3 to 4 d old. Some have catalytic properties. Trimethyltin chloride (TMT) is a stabilizer by-product in the process of manufacturing plastic, which is a kind of very strong toxic substance, and has acute, cumulative and chronic toxicity. TIN AND TIN COMPOUNDS . * Contact can severely irritate and burn the skin and eyes with possible eye damage. Ecological information Ecotoxicity Very toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment. Ruppert PH, Dean KF, Reiter LW. 16 (1985),229. This liquid, one of the simplest organotin compounds, is useful for transition-metal mediated conversion of acid chlorides to methyl ketones and aryl halides to aryl methyl ketones.It is volatile and toxic, so care should be taken when using it in the laboratory. (4) Chronic Effects (Noncancer): Chronic exposure of workers to triethylamine vapor has been observed to cause reversible corneal edema. (1,2) Acute exposure can irritate the skin and mucous membranes in humans. (1,3) Acute animal tests in rats, mice, and rabbits, have demonstrated triethylamine to have moderate acute toxicity from inhalation, moderate to high acute toxicity from oral exposure, and high acute toxicity from dermal exposure. et al., 1987). Hazardous to the aquatic environment, long-term (Chronic) - Category Chronic 1. SUMMARY 2.1 Main risks and target organs Trimethyltin (TMT) is a neurotoxin which damages areas of the limbic system, cerebral cortex, and the brainstem. In the present study, ginsenoside Rd was investigated as a candidate neuroprotective agent in a primary hippocampal neuron culture and mouse models. 56-24-6 - OJZNYUDKNVNEMV-UHFFFAOYSA-M - Trimethyltin hydroxide - Similar structures search, synonyms, formulas, resource links, and other chemical information. Snn is localized in tissues with known sensitivity to trimethyltin (TMT), including the central nervous system, immune system, spleen, kidney and lung. 28 (1926),367. Agency for Toxic Substances and Disease Registry. trimethyltin is toxic to neurons of the limbic system ( 5). TRIMETHYLTIN CHLORIDE is in the family of tin compounds widely used as stabilizers for plastics, additives to paint (as antifouling agents). There is clear evidence that the triethyltin and the trimethyltin are neurotoxic in experimental animals under certain conditions. There is inadequate evidence for the potential neurotoxic effect of chronic exposure to the organotin species that exist in the drinking water. toxicity from inhalation, moderate to high acute toxicity from oral exposure, and high acute toxicity from dermal exposure. Acute toxicity - Inhalation, Category 2. Tetramethyltin is an organometallic compound with the formula (CH 3) 4 Sn. Toxicity. * Contact can severely irritate and burn the skin and eyes with possible eye damage. In the present study, the embryo and larvae of sea urchin Strongylocentyotus intermedius were used as a model to investigate the toxic effects of TMT. Trimethyltin chloride (TMT) is an organotin contaminant, widely detected in aqueous environments, posing potential human and environmental risks. Different patterns and target tissues of toxicity may be predicted for the mono-and di- methyl-and butyltins found in the drinking water. Trimethyltin chloride (TMT) is a neurotoxicant that is widely present in the aquatic environment, primarily from the manufacture of PVC plastic, but few studies have evaluated aquatic neurotoxicity. In addition, we have performed experiments to identify the antiepileptic effects of … Toxicological information Acute Toxicity Product Information Component Information Toxicologically Synergistic Products No information available Trimethyltin-induced intoxication has a great impact on human health due to the widespread occurrence of methyltin compounds. * Trimethyltin Chloride may cause mutations. Their main hazard is associated with their high toxicity, in skin adsorption or inhalation. 11. Examples include butyl tin, dibutyl tin oxide. H330 (100%): Fatal if inhaled [Danger Acute toxicity, inhalation] H400 (100%): Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard] H410 (100%): Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard] Precautionary Statement Codes ABSTRACT Trimethyltin (TMT) is a selective and potent neurotoxicant capable of inducing apoptotic cell death in the hippocampal formation, neocortex, amygdala, and olfactory Cells in culture that do not express Snn show considerable resistance to TMT toxicity. Trimethyltin and triethyltin are mildly toxic to humans, whereas tripentyltin is generally non-toxic and is therefore applied as a pesticide. Trimethyltin thiocyanate Safety Profile Poison by intravenous route. The pathogenesis of trimethyltin chloride-induced nephrotoxicity. 1, 2 Cells in culture that do not express Snn show considerable resistance to TMT toxicity. May cause long-term adverse effects in the environment. A Toxicological Profile for Tin and Tin Compounds, Draft for Public Comment was released in September 2003. Tin tetra ethyl is absorbed rapidly by skin and mucous membranes, was found a nerve gas in animal tests, and may therefore be toxic to humans. Stannin (Snn) is a highly conserved, 88-amino acid protein that may mediate the selective toxicity of organotins. It is a white solid that is highly toxic and malodorous. Acute TMT intoxication in humans leads to a variety of neurological symptoms which involve primarily the limbic system. Toxicity from accidental exposure to alkyltins has lead to considerable research characterizing their selective toxicity in mammals (Boyer, 1989; Ross et al., 1981; Snoeij et al., 1987). Trimethyltin (TMT) is a toxic organotin compound that produces injury to the central nervous systems of mammals. iii UPDATE STATEMENT . In addition, the following controls are recommended: * Where possible, automatically transfer gaseous Trimethylamine or pump liquid Trimethylamine from cylinders or other storage containers to process containers. ). Trimethyltin-induced intoxication has a great impact on human health due to the widespread occurrence of methyltin compounds. This edition supersedes any previously released draft or final profile. toxic effects of TMT in rats and mice. 1. dni-rbt:oth 10 µg/L : JTEHD6 Journal of Toxicology and Environmental Health. Do not allow Handle with extreme caution. Stannin (Snn) is a highly conserved, 88-amino acid protein that may mediate the selective toxicity of organotins. High susceptibility of cortical neural progenitor cells to trimethyltin toxicity: involvement of both caspases and calpain in cell death. Organotin compounds such as trimethyltin chloride (TMT) are among the most toxic of the organometallics. 97 (1979),59. GHS Hazard Statements: H225 (100%): Highly Flammable liquid and vapor [Danger Flammable liquids]H300+H310+H330 (100%): Fatal if swallowed, in contact with skin or if inhaled [Danger Acute toxicity, oral; acute toxicity, dermal; acute toxicity, inhalation]H300 (100%): Fatal if swallowed [Danger Acute toxicity, oral]H310 (100%): Fatal in contact with skin [Danger Acute toxicity, dermal]
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